A New York City detective, Sara is a disciplined, tough-talking woman of Italian descent, who first encountered the Witchblade while on a case with her ex-partner, Michael Yee. After both officers were mortally wounded by criminal Ian Nottingham, the entity suddenly left the possession of Nottingham's employer, Kenneth Irons, and gave its power to Sara, healing her wounds. Pezzini has since been thrown into a darker world in which she's encountered a number of mystical opponents and strange cases while hosting The Witchblade. Quite often, she has wished for her life to return to normal.
Eventually, it was revealed that The Witchblade was actually the offspring of the universe's primal forces, The Angelus and The Darkness. When Jackie Estacado, the host of The Darkness, was "possessed" by its influence, he impregnated a temporarily comatose Sara as part of an effort to sway The Witchblade's balance. However, neither of them became aware of this until later.[4] Eventually, Sara met and relinquished The Witchblade to Dani Baptiste, whom the entity had a strong affinity toward. Coincidentally, Dani also happened to be the daughter of Sara's police captain. Amidst complications during the birth of her daughter, Hope, Sara's life was saved when she received half of The Witchblade from Dani. During this period, both women bore distinct visual effects when activating the gauntlet. Sara, formerly possessing the half infused with The Darkness, manifested a dark appearance and bat-like wings when flying, while Dani manifested a bright appearance with fairy-like wings during flight.
She now possesses the full Witchblade, as Dani is now the host for The Angelus
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